CALL FOR PAPERS Comparative Genomics Genomic analyses reveal a conserved glutathione homeostasis pathway in the invertebrate chordate Ciona intestinalis

Genomic analyses reveal a conserved glutathione homeostasis pathway in the invertebrate chordate Ciona intestinalis.

The major thiol redox buffer glutathione (l-gamma-glutamyl-l-cysteinylglycine, GSH) is central to cell fate determination, and thus, associated metabolic and regulatory pathways are exquisitely sensitive to a wide range of environmental cues. An imbalance of cellular redox homeostasis has emerged as a pathologic hallmark of a diverse range of human gene-environment disorders. Despite the centra...

Genomic studies using the invertebrate chordate Ciona intestinalis

Using a custom Ciona intestinalis genome browser to visualize genomic conservation with Ciona savignyi

We have successfully designed a custom genome browser for visualization of the genome of the invertebrate chordate Ciona intestinalis. We describe the use of the genome browser to visualize the conservation between Ciona intestinalis and a related species, Ciona savignyi. Visualizing genomic conservation between these two organisms is important for determining genes and regulatory regions that ...

Visualization of the invertebrate chordate Ciona intestinalis genome using a custom genome browser

With the sequencing of hundreds of genomes and the advent of high-throughput technologies able to produce high volumes of genomic information at increasingly faster rates and cheaper costs, there is a vital need for proper visualization tools for analyzing large amounts of genomic data. In this report, we implement a genome visualization tool for the model organism Ciona intestinalis. The tool ...

Unraveling genomic regulatory networks in the simple chordate, Ciona intestinalis.

The draft genome of the primitive chordate, Ciona intestinalis, was published three years ago. Since then, significant progress has been made in utilizing Ciona's genomic and morphological simplicity to better understand conserved chordate developmental processes. Extensive annotation and sequencing of staged EST libraries make the Ciona genome one of the best annotated among those that are pub...